strudy on the cardiovascular histaminergic receptors reactivity in experimental diabetes

This work was designed to investigate the reactivity of isolated hearts and aortic strips from normal rabbits and experimentally induced diabetic ones whether nontreated or treated with insulin or glybenclamide.In addition, the effect of cimetidine [H2 - blocker] and pheneramine maleate [HI - blocker] on the isolated rabbit hearts was studied in the 4 different groups.It was found that histamine induced a significant increase in the heart rate in a dose dependent manner in the control group with all doses used, and in the insulin and glybenclamide treated groups in the larger doses [50, 100 ug / ml]. Histamine also induced a significant increase in the amplitude of ventricular contraction in a dose dependant manner in the control and the insulin treated groups in all doses used and in the glybenclamide treated group with doses of 50, 100 ug/ ml but with a great significance In the diabetic group, this increase in the heart rate and the amplitude of ventricular contraction was found to be insignificant, However, there was a great significant reduction in the percentage of change in both parameters when compared to the control group. Histamine induced arrhythmia at a dose of 100 ug in the control, the insulin treated and the glybenclamide treated groups.With respect to the cardiac reactivity to hisamine antagonists, it was found that H2 blockers had a significant reduction in the heart rate and in the amplitude of ventricular contraction in the 4 groups studied without any significant change between them. Concerning the vascular reactivity to different doses of histamine, it was found that histamine induced a dose dependant increase in the tension developed, the time to reach maximum contraction and the time of maintained tone responses of aortic strips trom the 4 groups studied, No significant change was detected between the 4 different groups. However, it was clear that diabetes affected the vascular reactivity of rabbit aortic strips through significant prolongation in the time to reach relaxation in all doses used. In addition, insulin treatment decreased the time to reach relaxation response of the diabetic aortic strips, while glybenclamide treatment decreased it in one dose only, Therefore, it could be concluded that histamine has a positive inotropic and chronotropic effects while H2 blocking drugs have a cardiodepressant properties and that histamine in large doses causes arrhythmia and cardiac dysfunction. The.diabetic rabbit hearts have subnormal responsiveness to histamine stimulation and resist the occurrence of arrhythmia induced by histamine. This diabetic response can be completely normalized by insulin treatment, while glybenclamide treatment improves only the chronotropic response

Synovial fluid collagenase and acid prosphatase in rheumatoid arthritis and osteoarthritis

Svnovial fluid from the knee joints of 3l rheumatoid arthritis [RA] patients [17 active and 14 inactive] and 27 patients with osteoarthritis [OA] were studied to detect the enzymatic activity of collagenase and acid phosphatase. The activity of both enzymes showed a significant increase in patients with active RA than those with inactive disease synovial fluid collagenase and acid phosphatase in RA patients Showed a significant correlation with ESR, morning stiffness, Pain Score, articular index and grip strength while an insignificant correlation with age and disease duration was recorded. There was a significant increase in the activity of both enzymes in RA patients when compared with OA patients

Assessment of mucosal graft technique in management of biliary stricture

This study was conducted on nine patient who have biliary stricture [six of them were due to benign causes and three were due to cholangio carcinoma. All cases underwent biliary- enteric anastomosis using mucosal graft technique and followed up for six months. The results were good, no major complications or mortality. This study concluded that mucosal graft operation is an easy, safe and more rapid method of anastomosis and gave satisfactory results in the management of high biliary stricture whether benign or malignant